Can Weight Loss Reduce Psoriasis?



Revisiting methotrexate for psoriasis

Sign Up for Our Living with Psoriasis Newsletter

Thanks for signing up!

When it comes to treating psoriasis, sometimes the old becomes new. For the better part of five years I have treated my psoriasis with the newest, latest, and most technologically advanced biological drugs available. My basic treatment menu has included Amevive, Enbrel, and Humira. Each one's effectiveness varies and lasts for a limited time. Now that I am at yet another decision point I am rethinking using methotrexate (MTX).

According to the National Psoriasis Foundation, MTX was first used to treat cancer in the 1950's but they also found it could be used to treat psoriasis. It works to slow down the hyper proliferation of skin cells characteristic of psoriasis. Despite all the fancy new drugs out there, dermatologists still use MTX to control severe cases of psoriasis. My dermatologist asked me to consider using it again a couple weeks ago.

The main concern with MTX use is liver scarring. I'm not sure exactly what current practice is but in the past had two liver biopsies to check my liver. I started taking MTX in my early 20's while in college. MTX represented my first foray into systemic medications to control my psoriasis. My dermatologist in Sacramento (I went to school at UC Davis) wanted me to first get a baseline liver biopsy (depicted below). She explained to me that the biopsy is an outpatient minor surgical procedure where they grab a piece of my liver by placing a needle between my ribs. Okay, that's not the most technical way to say it but what I can say is that it hurt a lot more than I thought it would! Thankfully my liver was fine. The dermatologist told me that we would need to revisit the liver biopsy every 1.5-2 grams of MTX use.

I started with a few 2.5mg pills per week. My maximum dose was seven pills, or 17.5mg/week. I usually took it in split doses over a 24 hour period to minimize side effects such as nausea or fatigue. When those side effects increased I also took folic acid to mitigate those unwanted effects. I remember sharing about taking MTX with a colleague. She used a Chinese term to describe what she thought of the medicine: "du yao" or poison medicine. After a while the thought of taking it and the smell of the "poison medicine" made me want to gag but I continued on.

Back then it was a miracle drug for me as I cleared completely for some months. But once it lost effectiveness I broke out horribly. I stopped just before needing to take my third liver biopsy. Since I had good response the first time I went back to it about five years ago. Unfortunately, my body couldn't tolerate it. I endured nausea and fatigue for up to 72 hours or more after taking MTX. I tried taking MTX as an injection in my hip, prescription antacids to counter the acid in my stomach, and resting for long stretches. The second time around MTX neither cleared my skin nor allowed me to function much at all the days after taking it.

I never did have that third liver biopsy as I stopped just before crossing the 2 gram threshold. I was told that even if I had some minor damage the liver could recover from it after stopping. I don't drink alcohol but I was told to absolutely avoid alcoholic drinks while on MTX. Monthly blood tests also checked for liver function, blood counts, and any other potential abnormalities.

Of course, if you're thinking about taking MTX do some research for yourself and really talk it over with your doctors. I'm not sure if it's right for me this time around, especially given the way I reacted a few years ago. But I feel with psoriasis treatments I can't afford to completely eliminate potential options. I'm thinking of trying a smaller dose with Enbrel so I can stop taking Neoral for a while.

Last Updated:8/7/2008
Important:The views and opinions expressed in this article are those of the author and not Everyday Health.
Any opinions, advice, statements, services, advertisements, offers or other information or content expressed or made available through the Sites by third parties, including information providers, are those of the respective authors or distributors and not Everyday Health. Neither Everyday Health, its Licensors nor any third-party content providers guarantee the accuracy, completeness or usefulness of any content. Furthermore, neither Everyday Health nor its Licensors endorse or are responsible for the accuracy and reliability of any opinion, advice or statement made on any of the Sites or Services by anyone other than an authorized Everyday Health or Licensor representative while acting in his/her official capacity. You may be exposed through the Sites or Services to content that violates our policies, is sexually explicit or is otherwise offensive. You access the Sites and Services at your own risk. We take no responsibility for your exposure to third party content on the Sites or the Services. Everyday Health and its Licensors do not assume, and expressly disclaim, any obligation to obtain and include any information other than that provided to it by its third party sources. It should be understood that we do not advocate the use of any product or procedure described in the Sites or through the Services, nor are we responsible for misuse of a product or procedure due to typographical error.





Video: ESDV 2018 Annual Conference, Dr. Mohamed Banhawy Lecturing (Aspirin in Dermatology)

Revisiting methotrexate for psoriasis
Revisiting methotrexate for psoriasis images

2019 year
2019 year - Revisiting methotrexate for psoriasis pictures

Revisiting methotrexate for psoriasis advise
Revisiting methotrexate for psoriasis forecasting photo

Revisiting methotrexate for psoriasis images
Revisiting methotrexate for psoriasis pics

Revisiting methotrexate for psoriasis Revisiting methotrexate for psoriasis new photo
Revisiting methotrexate for psoriasis new pictures

pictures Revisiting methotrexate for psoriasis
photo Revisiting methotrexate for psoriasis

Watch Revisiting methotrexate for psoriasis video
Watch Revisiting methotrexate for psoriasis video

Discussion on this topic: Revisiting methotrexate for psoriasis, revisiting-methotrexate-for-psoriasis/
Discussion on this topic: Revisiting methotrexate for psoriasis, revisiting-methotrexate-for-psoriasis/ , revisiting-methotrexate-for-psoriasis/

Related News


What is the Difference Between Balayage and Ombre
No-Bake Berry-Orange Cheesecake Pie
How to Make a Cloth Bow
Diner Customer Leaves 3000 Tip on 40 Bill: Hopefully This Will Help All of You Have a Better Christmas
5 Cute Outfits When You Dont Know What to Wear
MTV VMAs 2019: Every Look from the RedCarpet
Is Oatmeal Good For Constipation
Patriotic Parfaits
Spiced Salmon Recipe
In-N-Out is no longer Americas favorite burger chain
30 Hottest Fringe Bangs Trending in 2019



Date: 16.12.2018, 21:54 / Views: 54382